rs798766

This IARC Advisory Group report assesses carcinogenic hazards and recommends priorities for the IARC Monographs during 2020-2024. The document reviews over 170 candidate agents including chemicals, biological agents, and environmental exposures, evaluating evidence of carcinogenicity in humans, experimental animals, and mechanistic pathways. It identifies one genetic variant (rs798766 in TMEM129-TACC3-FGFR3) relevant to bladder cancer susceptibility in occupational settings, but this is cited literature rather than original findings.

This case-control study of 231 bladder urothelial carcinoma (UC) patients and 261 benign controls found that rs9642880[T] and rs798766[T] variants increase bladder-UC risk (OR=1.72, p=0.028 and OR=1.84, p=0.01 respectively), but unlike upper tract UC, these variants are not associated with disease aggressiveness (grade or stage). The findings highlight distinct genetic differences between bladder-UC and upper urinary tract urothelial carcinoma.

This Iranian case-control study examined the association between the IGFBP-3 A-202C polymorphism (rs2854744) and bladder cancer risk in 162 cancer patients and 324 controls. The study found that the AA genotype was protective against bladder cancer (OR=0.48, 95% CI 0.24-0.64, P=0.001) while the AC genotype increased risk (OR=1.76, 95% CI 1.27-2.84, P=0.038). The protective effect of the AA genotype was more pronounced in advanced bladder cancers, with no AA genotype carriers having high-grade tumors.