rs7997012

This is a intronic variant in the HTR2A gene.

Key Literature Trait Associations

SSRI Antidepressant Response

HTR2A rs7997012 is an intronic variant in the serotonin 2A receptor gene. The AA genotype was significantly associated with better response to citalopram in the STAR*D clinical trial, one of the largest pharmacogenomic studies of antidepressant treatment. The mechanism likely involves altered HTR2A receptor expression in the prefrontal cortex, modulating serotonergic neurotransmission.

Werner R et al. “The A645D mutation in the hinge region of the human androgen receptor (AR) gene modulates AR activity, depending on the context of the polymorphic glutamine and glycine repeats.” The Journal of Clinical Endocrinology and Metabolism 91(9):3515-3520 (2006)
Allele A
OR —
p —
Candidate gene study
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ClinVar annotation

Drug Response★☆☆☆
2 submitters1 publication

Major depressive disorder, response to citalopram therapy in; not specified

View on ClinVar →
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Research that mentions this SNP (3)

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Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
ReviewRenan P. Souza et al.(2010)· Human Psychopharmacology: Clinical and Experimental

This systematic review of 98 studies examined biological predictors of clozapine response in treatment-resistant schizophrenia patients. Of 379 different gene variants investigated across 70 genetic studies, only three variants (DRD3 Ser9Gly rs6280, HTR2A His452Tyr, and GNB3 C825T) achieved independent replication. Non-genetic predictors included higher prefrontal cortical volumes and lower HVA:5-HIAA ratio in cerebrospinal fluid.

Traits studied:Clozapine responseSchizophreniaTreatment-resistant schizophrenia
PubMedDOIMetascience Observatory
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Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects
ReviewRenan P. Souza et al.(2009)· Human Psychopharmacology: Clinical and Experimental

A systematic review of 98 studies investigating biological predictors of clozapine response in treatment-resistant schizophrenia. Of 70 genetic studies examining 379 variants, only three genetic variants have independently replicated findings: DRD3 Ser9Gly (rs6280), HTR2A His452Tyr, and GNB3 C825T (rs5442/rs5443). Non-genetic predictors include higher prefrontal cortical structural integrity and activity, and lower HVA:5-HIAA ratio in cerebrospinal fluid.

Traits studied:Clozapine responseSchizophreniaTreatment-resistant schizophrenia
PubMedDOIMetascience Observatory
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Pharmacogenetics of Major Depression
ReviewMagnus Lekman et al.(2008)· Molecular Diagnosis & Therapy

This review examines pharmacogenetic findings from the STAR*D trial, a large-scale antidepressant treatment outcome study involving 1953 participants. Key findings include associations of rs1954787 (GRIK4) and rs7997012 (HTR2A) with better treatment response, rs1360780 (FKBP5) with rapid antidepressant response, and rs2818224 (GRIK2, OR ~8) and rs4825476 (GRIA3, OR 1.9) with treatment-emergent suicidal ideation.

Traits studied:Antidepressant Treatment RemissionAntidepressant Treatment ResponseMajor DepressionTreatment-Emergent Suicidal Ideation
DOIMetascience Observatory

Gene information from NCBI Gene. Variant classifications from ClinVar.

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