rs80045772

This variant is located in the CRIPTO gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

teratocarcinoma-derived growth factor 1 level

Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)

Allele A

OR 1.85

p 2.0e-45

N 466

Small GWAS

African American or Afro-Caribbean

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ClinVar annotation

Benign★☆☆☆

1 submitter

View on ClinVar →

About CRIPTO

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

View all CRIPTO variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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