rs80097705

This variant is located in the RAPGEF3 gene.

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ClinVar annotation

Benign★★★☆
3 submitters2 publications

not provided; Hepatocellular carcinoma; Malignant tumor of esophagus; Lung cancer; Cervical cancer; Colon adenocarcinoma; Acute myeloid leukemia; Uterine corpus endometrial carcinoma; Ovarian serous cystadenocarcinoma

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About RAPGEF3

Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and regulation of syncytium formation by plasma membrane fusion. Located in several cellular components, including filopodium; lamellipodium; and microvillus. Implicated in nicotine dependence. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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