rs8017161

This is a upstream gene variant variant in the EXOC3L4 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum gamma-glutamyl transferase measurement

Pazoki R et al. “Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.” Nature Communications 12(1):2579 (2021)

Allele G

OR 0.02

p 1.0e-300

N 437,194

Large GWAS

European

polymeric immunoglobulin receptor measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.04

p 2.0e-14

N 47,745

Large GWAS

European

biliary liver cirrhosis

Mells GF et al. “Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.” Nature Genetics 43(4):329-32 (2011)

Allele A

OR 1.22

p 3.0e-13

N 7,003

Large GWAS

European

About EXOC3L4

Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. [provided by Alliance of Genome Resources, Jul 2025]

View all EXOC3L4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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