rs8031948
This is a intron variant variant in the HYKK gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
FEV/FVC ratio, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele T
OR —
β 0.015
p 3.0e-15
N 13,532
Large GWAS
multi-ancestry
forced expiratory volume, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele T
OR —
β 0.075
p 3.0e-15
N 13,532
Large GWAS
multi-ancestry
pulmonary function measurement
Wilk JB et al. “Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.” American Journal of Respiratory and Critical Care Medicine 186(7):622-32 (2012)
Allele T
OR 1.22
p 3.0e-9
N 32,875
Large GWAS
European
About HYKK
Enables hydroxylysine kinase activity. Predicted to be involved in lysine catabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
View all HYKK variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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