rs8069451

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele C

OR 0.01

p 2.0e-22

N 2,669,029

Large GWAS

European

vital capacity

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele T

OR 0.02

p 7.0e-14

N 321,047

Large GWAS

European

forced expiratory volume

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele T

OR 0.02

p 2.0e-12

N 321,047

Large GWAS

European

asthma exacerbation measurement

Ahluwalia TS et al. “FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.” Nature Communications 11(1):6398 (2020)

Allele T

OR 0.22

p 4.0e-12

N 68,281

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…