rs8103278

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

beta-microseminoprotein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.03
p 3.0e-24
N 47,745
Large GWAS
European

eosinophil count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.02
p 1.0e-23
N 408,112
Large GWAS
European

BMI-adjusted waist-hip ratio, adult onset asthma

Zhu Z et al. “Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.” The Journal of Allergy and Clinical Immunology 145(2):537-549 (2020)
Allele G
OR —
p 1.0e-11
N 457,690
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist-hip ratio, asthma

Zhu Z et al. “Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.” The Journal of Allergy and Clinical Immunology 145(2):537-549 (2020)
Allele G
OR —
p 5.0e-11
N 457,690
Major Consortium StudyLarge GWAS
European

coronary artery disease

van der Harst P et al. “Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.” Circulation Research 122(3):433-443 (2018)
Allele A
OR 0.03
p 1.0e-8
N 250,736
Large GWAS

asthma

Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)
Allele G
OR 1.04
p 2.0e-10
N 771,388
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.05
p 8.0e-12
N 394,626
Large GWAS
European
Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)
Allele G
OR 1.04
p 1.0e-8
N 303,859
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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