rs821577

This is the first systematic study examining the role of DISC1 gene variants in adult ADHD. The intronic SNP rs1538979 was associated with ADHD in a Norwegian sample (OR 1.33, p=0.03) and replicated in a Spanish sample using the tagging SNP rs11122330 (meta-analysis p=0.008, OR 1.25). Additionally, the non-synonymous variant rs6675281 (Phe607Leu) was associated with positive bipolar spectrum symptoms as measured by the Mood Disorder Questionnaire (OR 1.44, p=0.01) in the Norwegian sample, though this was not replicated.

Association study of 41 SNPs in DISC1 with psychosis-related traits (social anhedonia, physical anhedonia, perceptual aberration, schizoidia) in 4,651 participants from a Finnish birth cohort. Carriers of the minor allele of rs821577 had significantly higher social anhedonia scores (P<.001, d=0.09), and rs821633 showed significant interaction effects with rs821577 and rs1538979 on anhedonia phenotypes (P<.001, d=0.07-0.14).