rs853974
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 2 diabetes mellitus
Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele C
OR 0.06
p 7.0e-25
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry
Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)
Allele C
OR 0.06
p 8.0e-12
N 659,316
Large GWAS
multi-ancestry
brain volume
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.07
p 8.0e-12
N 21,282
Major Consortium StudyLarge GWAS
European
total cortical area measurement
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.07
p 2.0e-10
N 21,282
Major Consortium StudyLarge GWAS
European
thalamus volume
Elvsåshagen T et al. “The genetic architecture of the human thalamus and its overlap with ten common brain disorders.” Nature Communications 12(1):2909 (2021)
Allele T
OR 30.54
p 4.0e-9
N 30,114
Large GWAS
European
sclerosing cholangitis
Alberts R et al. “Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.” Gut 67(8):1517-1524 (2018)
Allele A
OR —
p 6.0e-9
N 3,318
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…