rs860598
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
insulin measurement
▶Research that mentions this SNP (2)
▶Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortiumAssociationN=26,760Stephanie A. Bien et al.(2017)· Diabetologia
Transethnic fine-mapping study of glycaemic traits in 26,760 participants (Hispanic/Latino, African, Asian, and Native American) using the Metabochip. Replicated 31/39 fasting glucose and 14/17 fasting insulin loci from European GWAS. Identified two novel secondary signals at G6PC2-rs477224 and GCK-rs2908290, a population-specific signal at G6PC2-rs77719485 in African ancestry, and one novel locus at SLC17A2-rs75862513 for fasting insulin.
▶Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorderAssociationN=1,878Ana C. Parente Pereira et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A genome-wide association study (GWAS) of 506-937 bipolar affective disorder cases and 510-990 controls identified multiple SNPs in the IGF1 gene associated with bipolar disorder, with four SNPs showing p-values of 3.7×10⁻⁵, 8.4×10⁻⁴, 2.6×10⁻⁴, and 2.5×10⁻⁴. Resequencing identified novel variants in IGF1, including rs5742620 (p=0.0454) and rs78352613 (p=0.006) in the promoter region. Gene-wide analysis and haplotypic association confirmed IGF1 as a candidate susceptibility gene for bipolar disorder with dominant inheritance pattern.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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