rs8688

This variant is located in the TTC9 gene.

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Research that mentions this SNP (1)

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Substance dependence low-density whole genome association study in two distinct American populations
AssociationN=1,699Yi Yu et al.(2008)· Human Genetics

Family-based genome-wide association study of substance dependence in 1,699 subjects from 673 families (339 African American, 334 European American families) using 5,633 SNP markers. The study identified 56 significant associations across cocaine dependence, opioid dependence, nicotine dependence, alcohol dependence, and cocaine-induced paranoia. The strongest association was rs1133503 in MANEA gene with cocaine-induced paranoia (p=0.00005). Other notable findings include associations between NAV3 and opioid dependence, SYT13 and cocaine dependence, and PLEKHG1 with nicotine dependence scores.

Traits studied:Alcohol dependenceCocaine dependenceCocaine-induced paranoiaFagerstrom Test for Nicotine DependenceNicotine dependenceOpioid dependence
PubMedDOIMetascience Observatory

About TTC9

This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]

View all TTC9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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