rs871135
This variant is located in the POU5F1B gene.
▶Research that mentions this SNP (2)
▶Meta‐analysis of genome‐wide and replication association studies on prostate cancerAssociationN=916Hong Liu et al.(2011)· The Prostate
A case-control study of 489 prostate cancer cases and 427 controls in a New Zealand Caucasian population examined 15 chromosome 8q24 SNPs. Four SNPs showed statistically significant associations with prostate cancer risk: rs10086908 (T allele, OR=1.64), rs16901979 (A allele, OR=2.58), rs1447295 (A allele, OR=1.70), and rs4242382 (A allele, OR=1.60). A weighted genetic risk score based on all 15 SNPs was significantly associated with prostate cancer risk (OR=1.10), with smoking contributing additional risk.
▶Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestryAssociationN=1,163Prodipto Pal et al.(2009)· The Prostate
This case-control study of 596 prostate cancer cases and 567 controls tested 49 tagging SNPs in the 8q24 region for association with prostate cancer susceptibility and tumor aggressiveness in men of European ancestry. After multiple testing correction, four SNPs showed significant association with PC susceptibility (rs1016342, rs1378897, rs871135, rs6470517), while rs6470517 was significantly associated with aggressive tumor phenotypes (Gleason score and TNM staging, P = 10^-4 to 10^-5). Meta-analysis of rs1447295 showed a pooled odds ratio of 1.38 (95% CI: 1.30-1.46).
About POU5F1B
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
View all POU5F1B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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