rs885389
This is a regulatory region variant variant in the ADGRD1 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
appendicular lean mass
Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele A
OR 0.03
p 6.0e-37
N 450,243
Major Consortium StudyLarge GWAS
European
body height
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.01
p 1.0e-22
N 928,679
Large GWAS
multi-ancestry
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.01
p 1.0e-11
N 394,642
Large GWAS
European
RR interval
Marroni F et al. “A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.” Circulation. Cardiovascular Genetics 2(4):322-8 (2009)
Allele A
OR 0.17
p 4.0e-8
N 2,325
Large GWAS
European
About ADGRD1
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]
View all ADGRD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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