rs890
This is a 3 prime utr variant variant in the GRIN2B gene.
▶ClinVar annotation
▶Research that mentions this SNP (5)
▶A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depressionAssociationN=1,569Chen Zhang et al.(2014)· Psychopharmacology
A case-control association study of GRIN2B variants in treatment-resistant depression (TRD) among Han Chinese patients. Four SNPs (rs1805502, rs890, rs1806201, rs7301328) were genotyped in 178 TRD patients, 612 non-TRD patients, and 779 controls. Rs1805502 showed significant association with TRD (OR=1.55, 95% CI=1.18-2.05, corrected P=0.008), and the G-T haplotype (rs1805502/rs890) was significantly overrepresented in TRD patients (corrected P=0.007).
▶Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive–compulsive symptomsAssociationN=250Jun Cai et al.(2013)· Psychopharmacology
This study examined whether polymorphisms in glutamate-related genes SLC1A1, GRIN2B, and GRIK2 are associated with clozapine-induced obsessive-compulsive symptoms in 250 Han Chinese schizophrenia patients. Rs890 (GRIN2B) showed significant association with OC symptoms (OR=1.75, p=0.002), while rs2228622 (SLC1A1) showed trends (OR=1.68, p=0.017). A significant gene-gene interaction between rs2228622 and rs890 was identified (p=0.0021), with AA/TT genotypes showing elevated symptom severity.
▶Association of GRIN1 and GRIN2A‐D With schizophrenia and genetic interaction with maternal herpes simplex virus‐2 infection affecting disease riskAssociationN=2,484Ditte Demontis et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This Danish case-control association study examined SNP variations in GRIN1 and GRIN2A-D genes (encoding NMDA receptor subunits) in 984 schizophrenia cases and 1,500 controls. Nine SNPs in GRIN2B were significantly associated with schizophrenia, with rs1806194 remaining significant after Bonferroni correction (P=0.0008). Notably, strong gene-environment interactions were found between GRIN2B genetic variation and maternal HSV-2 infection in 365 cases and 365 controls, with rs1805539 (P=0.0001) and rs1806205 (P=0.0008) remaining significant after correction.
▶Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjectsReviewRenan P. Souza et al.(2009)· Human Psychopharmacology: Clinical and Experimental
A systematic review of 98 studies investigating biological predictors of clozapine response in treatment-resistant schizophrenia. Of 70 genetic studies examining 379 variants, only three genetic variants have independently replicated findings: DRD3 Ser9Gly (rs6280), HTR2A His452Tyr, and GNB3 C825T (rs5442/rs5443). Non-genetic predictors include higher prefrontal cortical structural integrity and activity, and lower HVA:5-HIAA ratio in cerebrospinal fluid.
▶NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific mannerAssociationN=812Larissa Arning et al.(2007)· Human Genetics
This association study examined genetic modifiers of age at onset in Huntington disease (HD) by fine-mapping GRIN2A and GRIN2B glutamate receptor genes in 250 HD patients. The study identified sex-specific effects, with GRIN2B C2664T (rs1806201) showing significant association in females (R²=0.56, p=0.005) but not males. Combined GRIN2A and GRIN2B variants explained 7.2% additional variance in age at onset beyond the pathogenic CAG repeat expansion.
About GRIN2B
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]
View all GRIN2B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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