rs892145
This is a protein-altering variant in the PGLYRP2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
guanylyl cyclase-activating protein 1 measurement
▶Research that mentions this SNP (1)
▶Peptidoglycan recognition protein genes and risk of Parkinson's diseaseAssociationN=990Goldman SM et al.(2014)· Movement Disorders
Case-control genetic association study of 990 participants (480 cases, 510 controls) from two independent cohorts testing 30 SNPs across four PGLYRP genes (encoding peptidoglycan recognition proteins) for association with Parkinson's disease risk. Variants in PGLYRP2 (rs3813135, rs733731, rs892145), PGLYRP3 (rs2987763), and PGLYRP4 (rs10888557, rs12063091, rs3006440, rs3006448, rs3006458, rs3014864) were significantly associated with PD risk. The strongest association was PGLYRP4 rs10888557 (5'UTR), where the CC genotype showed OR 0.15 (95% CI 0.04-0.6) compared to GG reference (P-trend = 0.0004). Most minor alleles were associated with reduced PD risk, consistent with a role for gut microbiota and immune response in disease pathogenesis.
About PGLYRP2
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
View all PGLYRP2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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