rs917727
This variant is located in the FAM3C gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
bone tissue density
Medina-Gomez C et al. “Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.” Plos Genetics 8(7):e1002718 (2012)
Allele T
OR 0.15
p 1.0e-27
N 2,659
Meta-analysis
European
Medina-Gomez C et al. “Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.” Nature Communications 8(1):121 (2017)
Allele T
OR 0.13
p 5.0e-17
N 10,414
Meta-analysisLarge GWAS
European, NR
bone tissue density, lean body mass
Medina-Gomez C et al. “Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.” Nature Communications 8(1):121 (2017)
Allele T
OR —
p 3.0e-20
N 10,414
Meta-analysisLarge GWAS
European, NR
upper extremity fracture
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.10
p 3.0e-17
N 625,385
Major Consortium StudyLarge GWAS
multi-ancestry
About FAM3C
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
View all FAM3C variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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