rs921146

This variant is located in the CASC8 gene.

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Research that mentions this SNP (1)

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Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
AssociationN=1,163Prodipto Pal et al.(2009)· The Prostate

This case-control study of 596 prostate cancer cases and 567 controls tested 49 tagging SNPs in the 8q24 region for association with prostate cancer susceptibility and tumor aggressiveness in men of European ancestry. After multiple testing correction, four SNPs showed significant association with PC susceptibility (rs1016342, rs1378897, rs871135, rs6470517), while rs6470517 was significantly associated with aggressive tumor phenotypes (Gleason score and TNM staging, P = 10^-4 to 10^-5). Meta-analysis of rs1447295 showed a pooled odds ratio of 1.38 (95% CI: 1.30-1.46).

Traits studied:Prostate cancer aggressivenessProstate cancer susceptibilityTumor grade (Gleason score)Tumor stage (TNM staging)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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