rs9257809
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sarcoidosis
Rivera NV et al. “High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.” American Journal of Respiratory and Critical Care Medicine 193(9):1008-22 (2016)
Allele G
OR —
p 1.0e-20
N 1,048
Large GWAS
European
fatty acid amount
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 2.0e-11
N 128,922
Large GWAS
European
Barrett's esophagus
Su Z et al. “Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.” Nature Genetics 44(10):1131-6 (2012)
Allele A
OR 1.21
p 4.0e-9
N 7,024
Large GWAS
European
Gharahkhani P et al. “Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.” The Lancet. Oncology 17(10):1363-1373 (2016)
Allele A
OR 1.26
p 6.0e-9
N 23,326
Meta-analysisLarge GWAS
European
esophageal adenocarcinoma, Barrett's esophagus
Gharahkhani P et al. “Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.” The Lancet. Oncology 17(10):1363-1373 (2016)
Allele A
OR 1.23
p 6.0e-9
N 27,438
Meta-analysisLarge GWAS
European
breast carcinoma
Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)
Allele G
OR 0.06
p 3.0e-8
N 139,274
Large GWAS
multi-ancestry
saturated fatty acids measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 4.0e-8
N 128,922
Large GWAS
European
Tinnitus
Clifford RE et al. “Genetic architecture distinguishes tinnitus from hearing loss.” Nature Communications 15(1):614 (2024)
Allele A
OR 5.46
p 5.0e-8
N 596,905
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma riskAssociationN=1,036Polat Dura et al.(2013)· International Journal of Cancer
Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk
AssociationN=1,036Polat Dura et al.(2013)· International Journal of Cancer
This Dutch case-control study (431 esophageal cancer patients, 605 controls) examined whether Barrett's esophagus-associated variants also increase esophageal cancer risk. MHC rs9257809 G allele increased esophageal squamous cell carcinoma (ESCC) risk (OR 1.76, 95% CI 1.16-2.66), while FOXF1 rs9936833 C allele increased esophageal adenocarcinoma (EAC) risk (OR 1.21, 95% CI 0.99-1.47).
Traits studied:Barrett's esophagusEsophageal adenocarcinomaEsophageal squamous cell carcinoma
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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