rs9271588

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

myeloid leukocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.06
p 9.0e-68
N 169,219
Large GWAS
European

granulocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.06
p 2.0e-66
N 169,822
Large GWAS
European

neutrophil count, eosinophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.06
p 4.0e-66
N 170,384
Large GWAS
European

neutrophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.06
p 1.0e-58
N 170,702
Large GWAS
European

neutrophil count, basophil count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.06
p 2.0e-58
N 170,143
Large GWAS
European

Sjogren syndrome

Li Y et al. “A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.” Nature Genetics 45(11):1361-5 (2013)
Allele T
OR 1.75
p 9.0e-37
N 1,592
Large GWAS
East Asian

wheat allergic reaction

Noguchi E et al. “HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy.” The Journal of Allergy and Clinical Immunology 144(5):1354-1363 (2019)
Allele G
OR 2.30
p 1.0e-26
N 3,152
Large GWAS
East Asian

extranodal nasal NK/T cell lymphoma

Lin GW et al. “Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations.” The Lancet. Oncology 21(2):306-316 (2020)
Allele C
OR 1.53
p 9.0e-26
N 8,452
Large GWAS
East Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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