rs9273349

This variant is located in the HLA-DQB1-AS1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Moffatt MF et al. “A large-scale, consortium-based genomewide association study of asthma.” The New England Journal of Medicine 363(13):1211-1221 (2010)
Allele C
OR 1.18
p 7.0e-14
N 26,475
Major Consortium StudyLarge GWAS
European, Other

gastric triacylglycerol lipase measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.04
p 4.0e-13
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes
AssociationN=10,320Nada M. Saleh et al.(2011)· Diabetes/Metabolism Research and Reviews

This candidate gene association study examined genetic variants in atopic disease and proinflammatory cytokine genes for association with type 1 diabetes in 6,743-10,320 cases and 7,864-9,354 controls. The FLG R501X/rs61816761 (p=0.82), SELS -105/rs28665122 (p=0.08), and IL18 SNPs showed no association with T1D. However, four loci previously associated with asthma also showed significant association with T1D: HLA, GSDMB/ORMDL3/GSDMA (rs2305480, rs3894194, p≤1.2×10⁻⁶), and IL2RB (rs2284033, p=0.005), suggesting shared genetic susceptibility between atopic and autoimmune diseases.

Traits studied:AsthmaAtopic dermatitisAtopyType 1 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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