rs9275596

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IGA glomerulonephritis

Kiryluk K et al. “Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.” Nature Genetics 46(11):1187-96 (2014)

Allele T

OR 1.44

p 3.0e-31

N 6,699

Large GWAS

multi-ancestry

Li M et al. “Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.” Journal of the American Society of Nephrology : Jasn 31(12):2949-2963 (2020)

Allele T

OR 1.44

p 2.0e-13

N 14,191

Meta-analysisLarge GWAS

multi-ancestry

Zhang YM et al. “Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE.” Molecular Genetics and Genomics : Mgg 296(4):1017-1026 (2021)

Allele T

OR —

p 6.0e-10

N 2,079

Large GWAS

East Asian

peanut allergy measurement

Hong X et al. “Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.” Nature Communications 6:6304 (2015)

Allele C

OR 1.70

p 6.0e-11

N 2,197

Large GWAS

European

omega-6 polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 6.0e-10

N 239,268

Large GWAS

European

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Research that mentions this SNP (1)

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Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India

AssociationN=503Arghya Laha et al.(2020)· Immunogenetics

This case-control association study examined HLA-DQ rs9275596, IL13 rs20541, and IL13 rs1800925 polymorphisms in 378 shrimp-allergic patients and 125 controls from West Bengal, India. Risk genotypes HLA-DQ rs9275596 CC (OR=2.88, P=0.04), IL13 rs20541 AA (OR=3.60, P=0.01), and IL13 rs1800925 TT (OR=5.48, P=0.03) were significantly associated with challenge-proven shrimp allergy and elevated shrimp-specific IgE levels. The IL13 TA haplotype showed significant association with shrimp allergy and had synergistic effects with the HLA-DQ CC genotype in elevating specific IgE (P=0.03).

Traits studied:Food allergyShrimp allergy

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs9275596

GWAS Catalog Trait Associations (3)

IGA glomerulonephritis

peanut allergy measurement

omega-6 polyunsaturated fatty acid measurement

Research that mentions this SNP (1)

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