rs9276370

This variant is located in the HLA-DQA2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronic hepatitis B virus infection

Chang SW et al. “A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.” Plos One 9(6):e99724 (2014)

Allele T

OR 1.95

p 2.0e-12

N 625

Small GWAS

East Asian

About HLA-DQA2

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

View all HLA-DQA2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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