rs9276427

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Oral ulcer

Dudding T et al. “Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.” Nature Communications 10(1):1052 (2019)
Allele C
OR 1.03
p 2.0e-10
N 461,106
Large GWAS
European, NR

age at first birth measurement

Mills MC et al. “Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.” Nature Human Behaviour 5(12):1717-1730 (2021)
Allele T
OR 0.05
p 3.0e-8
N 542,901
Large GWAS
European

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele C
OR 0.02
p 3.0e-8
N 219,872
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist-hip ratio

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele C
OR 0.02
p 1.0e-8
N 219,872
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (1)

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Genetic Variations at Loci Involved in the Immune Response Are Risk Factors for Hepatocellular Carcinoma
AssociationN=1,159Robert J. Clifford et al.(2010)· Hepatology

Genome-wide association study identifying genetic variations affecting hepatocellular carcinoma (HCC) susceptibility in Korean populations. Strong associations found with CNV at T-cell receptor loci (TRA@, TRG@; P < 1×10^-15) and SNPs in MHC class II regions (rs9267673, rs2647073, rs3997872). Antigen presentation and processing pathway showed highly significant association (P = 1×10^-11). TPTE2 SNP rs2880301 distinguished HCC from cirrhosis (P = 1.74×10^-12).

Traits studied:Hepatocellular carcinomaLiver cirrhosisPrimary liver cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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