rs9276975

This is a 3 prime utr variant variant in the HLA-DOA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

white wine liking measurement

Pirastu N et al. “Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.” European Journal of Human Genetics : Ejhg 23(12):1717-22 (2015)

Allele T

OR —

β 0.054

p 2.0e-8

N 2,240

Large GWAS

multi-ancestry

About HLA-DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

View all HLA-DOA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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