rs928413
This is a upstream gene variant variant in the IL33 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
childhood onset asthma
Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.19
p 2.0e-40
N 327,670
Large GWAS
European
Bønnelykke K et al. “A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.” Nature Genetics 46(1):51-5 (2014)
Allele G
OR 1.24
p 9.0e-13
N 3,684
Large GWAS
multi-ancestry
adult onset asthma
Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.19
p 5.0e-17
N 339,801
Large GWAS
European
asthma, age at onset
Sarnowski C et al. “Identification of a new locus at 16q12 associated with time to asthma onset.” The Journal of Allergy and Clinical Immunology 138(4):1071-1080 (2016)
Allele G
OR 1.19
p 7.0e-16
N 13,886
Large GWAS
European
asthma
Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR —
p 5.0e-11
N 37,846
Large GWAS
European
chronic obstructive pulmonary disease
Cosentino J et al. “Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.” Nature Genetics 55(5):787-795 (2023)
Allele G
OR 0.01
p 2.0e-10
N 325,027
Large GWAS
European
allergic disease, age at onset
Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele G
OR 0.03
p 3.0e-9
N 117,130
Large GWAS
European
About IL33
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
View all IL33 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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