rs9290663
This is a intron variant variant in the KCNMB2 gene.
▶Research that mentions this SNP (1)
▶Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese populationAssociationN=1,579Songyu Cao et al.(2016)· Journal of Cancer Research and Clinical Oncology
Replication study in a Chinese population confirming associations between 16 SNPs and acute myeloid leukemia (AML) risk identified in European GWAS studies. Seven SNPs showed significant associations with AML susceptibility, including rs2191566 (OR=1.46), rs9290663 (OR=1.26), rs11155133 (OR=1.32), rs10873876 (OR=0.62, protective), rs2239633, rs10821936, and rs2242041, in a case-control study of 545 AML cases and 1034 controls.
About KCNMB2
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
View all KCNMB2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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