rs9295536
This is a downstream gene variant variant in the CASC15 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroblastoma
Diskin SJ et al. “Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.” Nature Genetics 44(10):1126-30 (2012)
Allele A
OR 1.36
p 8.0e-16
N 6,303
Large GWAS
multi-ancestry
migraine disorder
Hautakangas H et al. “Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.” Nature Genetics 54(2):152-160 (2022)
Allele C
OR 1.04
p 8.0e-12
N 873,341
Large GWAS
European
About CASC15
This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]
View all CASC15 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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