rs9297758
This is a intron variant variant in the CASC8 gene.
▶Research that mentions this SNP (2)
▶Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese populationAssociationN=2,434Guoye Liu et al.(2020)· Journal of Clinical Laboratory Analysis
This case-control study examined associations between lncRNA CASC8 genetic polymorphisms and tuberculosis (TB) susceptibility in 900 Chinese TB patients and 1534 healthy controls. The rs7836840 C allele showed significant association with TB risk (OR = 1.196, 95% CI = 1.05-1.362, P = .027 after Bonferroni correction) in pulmonary TB subtype analysis. Variants rs7825118, rs9297758, and rs6981424 were associated with clinical TB manifestations including hemoglobin levels, neutrophil counts, and liver enzyme activity.
▶Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestryAssociationN=1,163Prodipto Pal et al.(2009)· The Prostate
This case-control study of 596 prostate cancer cases and 567 controls tested 49 tagging SNPs in the 8q24 region for association with prostate cancer susceptibility and tumor aggressiveness in men of European ancestry. After multiple testing correction, four SNPs showed significant association with PC susceptibility (rs1016342, rs1378897, rs871135, rs6470517), while rs6470517 was significantly associated with aggressive tumor phenotypes (Gleason score and TNM staging, P = 10^-4 to 10^-5). Meta-analysis of rs1447295 showed a pooled odds ratio of 1.38 (95% CI: 1.30-1.46).
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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