rs9299525

This variant is located in the SAMD8 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 1.0e-11

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

triglyceride measurement, peripheral arterial disease, coronary artery disease

Bellomo TR et al. “Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci.” Frontiers in Genetics 12:787545 (2021)

Allele G

OR —

p 6.0e-10

N 1,445,253

Large GWAS

European

About SAMD8

Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Located in cytosol and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

View all SAMD8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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