rs9320913

This is a intron variant variant.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

self reported educational attainment

Rietveld CA et al. “GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.” Science (new York, N.y.) 340(6139):1467-71 (2013)
Allele A
OR 0.10
p 4.0e-10
N 101,069
Large GWAS
European

intelligence

Sniekers S et al. “Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.” Nature Genetics 49(7):1107-1112 (2017)
Allele A
OR 5.75
p 9.0e-9
N 78,308
Meta-analysisLarge GWAS
European
▶

Research that mentions this SNP (1)

▶
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
AssociationN=20,495Joey W. Trampush et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A GWAS replication study demonstrating that rs1906252 (6q16.1, in an intron of lincRNA RP11-436D23.1) is independently associated with general cognitive ability (g factor) across 20,495 COGENT participants (beta=0.031, p=1.47×10⁻⁴). The minor A allele was associated with higher cognitive scores; meta-analysis combining COGENT and SSGAC (43,381 samples) yielded p=4.94×10⁻⁷. The locus was previously identified in an educational attainment GWAS, confirming shared genetic architecture between cognitive ability and educational outcomes.

Traits studied:Cognitive functionEducational attainmentGeneral cognitive abilityProcessing speed
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…