rs9332239

This is a missense variant in the CYP2C9 gene.

Key Literature Trait Associations

CYP2C9 Drug Metabolism

CYP2C9*4 carries an I359T substitution — similar but distinct from the more common *3 allele (I359L). This rare reduced-function variant contributes to CYP2C9 metabolizer variability primarily in European populations. It affects metabolism of warfarin, phenytoin, NSAIDs, and other CYP2C9 substrates.

Shams ME et al. “CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.” Journal of Clinical Pharmacy and Therapeutics 31(5):493-502 (2006)

Allele T

OR —

p —

Candidate gene study

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…