rs9379862

This is a synonymous variant in the BTN3A2 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood immunoglobulin amount

Butler-Laporte G et al. “Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study.” Open Forum Infectious Diseases 7(11):ofaa450 (2020)
Allele T
OR 0.10
p 1.0e-8
N 8,518
Large GWAS
European

depressive symptom measurement

Li ZY et al. “Whole exome sequencing identified six novel genes for depressive symptoms.” Molecular Psychiatry 30(5):1925-1936 (2025)
Allele C
OR 0.01
p 3.0e-8
N 296,199
Large GWAS
European

About BTN3A2

This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

View all BTN3A2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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