rs9387522
This is a 3 prime utr variant variant in the MANEA gene.
▶Research that mentions this SNP (1)
▶Association of Variants in MANEA With Cocaine-Related BehaviorsAssociationN=3,992Lindsay A. Farrer et al.(2009)· Archives of General Psychiatry
This association study of 3,992 individuals from 2 family-based and 2 case-control samples examined the MANEA gene variants in relation to cocaine dependence (CD) and cocaine-induced paranoia (CIP). The rs9387522 A allele in the 3' untranslated region was associated with increased risk of CIP across all 4 data sets (P < 0.001), with strongest evidence for CIP associations in the MANEA promoter and coding regions (P < 0.001). Haplotype analysis identified the T-T-A and C-T-A haplotypes as conferring increased CIP risk while C-A-C haplotype decreased risk, suggesting the functional variant likely resides in the MANEA promoter or 3' UTR region.
About MANEA
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
View all MANEA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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