rs9391855

This is a downstream gene variant variant in the AGER gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronic obstructive pulmonary disease

Cosentino J et al. “Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.” Nature Genetics 55(5):787-795 (2023)

Allele C

OR 0.08

p 3.0e-83

N 325,027

Large GWAS

European

protein measurement

Western D et al. “Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.” Nature Genetics 56(12):2672-2684 (2024)

Allele T

OR 0.77

p 3.0e-32

N 3,506

Large GWAS

European

FEV/FVC ratio

Zhu Z et al. “A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity.” The European Respiratory Journal 58(4) (2021)

Allele C

OR —

β 0.053

p 2.0e-22

N 100,285

Large GWAS

East Asian

mean arterial pressure

Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)

Allele C

OR 0.58

p 2.0e-15

N 100,453

Large GWAS

East Asian

level of syndecan-1 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.08

p 2.0e-13

N 47,745

Large GWAS

European

level of protein Wnt-9a in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.08

p 1.0e-11

N 47,745

Large GWAS

European

diastolic blood pressure

Allele C

OR 0.52

p 1.0e-16

N 100,453

Large GWAS

East Asian

About AGER

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

rs9391855

GWAS Catalog Trait Associations (7)

chronic obstructive pulmonary disease

protein measurement

FEV/FVC ratio

mean arterial pressure

level of syndecan-1 in blood

level of protein Wnt-9a in blood

diastolic blood pressure

About AGER

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