rs945270

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

putamen volume

Satizabal CL et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature Genetics 51(11):1624-1636 (2019)
Allele C
OR 15.30
p 7.0e-53
N 37,571
Large GWAS
multi-ancestry

brain volume

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele G
OR 0.12
p 1.0e-36
N 21,282
Major Consortium StudyLarge GWAS
European

brain volume, putamen volume

Hibar DP et al. “Common genetic variants influence human subcortical brain structures.” Nature 520(7546):224-9 (2015)
Allele C
OR 48.89
p 1.0e-33
N 13,171
Large GWAS
multi-ancestry

pallidum volume

Satizabal CL et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature Genetics 51(11):1624-1636 (2019)
Allele C
OR 7.44
p 1.0e-13
N 34,413
Large GWAS
multi-ancestry

caudate nucleus volume

Satizabal CL et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature Genetics 51(11):1624-1636 (2019)
Allele C
OR 5.92
p 3.0e-9
N 37,741
Large GWAS
multi-ancestry

nucleus accumbens volume

Satizabal CL et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature Genetics 51(11):1624-1636 (2019)
Allele C
OR 5.79
p 7.0e-9
N 32,562
Large GWAS
multi-ancestry

neuroimaging measurement

Fu J et al. “Cross-ancestry genome-wide association studies of brain imaging phenotypes.” Nature Genetics 56(6):1110-1120 (2024)
Allele G
OR 0.15
p 1.0e-16
N 7,058
Large GWAS
East Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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