rs9470794

This is a intron variant variant in the ZFAND3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Cho YS et al. “Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.” Nature Genetics 44(1):67-72 (2011)
Allele C
OR 1.12
p 2.0e-10
N 18,817
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes
AssociationN=5,674Rashmi B. Prasad et al.(2016)· Diabetologia

Family-based study examining parent-of-origin effects (POE) on type 2 diabetes risk in 4,211 individuals from Botnia and 1,463 from the Hungarian Transdanubian Biobank. Three loci showed nominal POE, with the strongest signal at rs7578597 in THADA showing excess maternal transmission of the risk T allele to diabetic offspring (Botnia pPOE=0.01, HTB pPOE=0.045, combined pPOE=0.0006). Five CpG sites flanking rs7578597 showed differential methylation between diabetic and non-diabetic islets, supporting potential THADA imprinting. Meta-analysis confirmed association with type 2 diabetes (OR=1.24, 95% CI 1.12-1.36, p=1.96×10⁻⁵).

Traits studied:BMIBlood pressureGlucose toleranceHyperglycaemiaImpaired fasting glucose (IFG)Impaired glucose tolerance (IGT)Insulin secretionInsulin sensitivityLipidsType 2 diabetesWaist-to-hip circumference ratio
PubMedDOIMetascience Observatory

About ZFAND3

Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

View all ZFAND3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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