rs9543325

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pancreatic carcinoma

Klein AP et al. “Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.” Nature Communications 9(1):556 (2018)
Allele C
OR 1.24
p 1.0e-22
N 21,536
Meta-analysisLarge GWAS
European
Petersen GM et al. “A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.” Nature Genetics 42(3):224-8 (2010)
Allele C
OR 1.26
p 3.0e-11
N 7,785
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility
AssociationN=19,862Chiara Corradi et al.(2021)· International Journal of Cancer

Genome-wide scan of long noncoding RNA (lncRNA) variants in 19,862 individuals identified five novel lncSNP associations with pancreatic ductal adenocarcinoma (PDAC) risk. The strongest association was rs7046076 (C allele, OR=1.13, 95% CI=1.09-1.18, P=9.73×10⁻⁹) in the NONHSAG053086.2/lnc-SMC2-1 lncRNA, which disrupts binding to hsa-mir-1256, regulating genes including CDKN2B and DAAM1 involved in cell cycle control and cell migration.

Traits studied:Pancreatic cancerPancreatic ductal adenocarcinoma (PDAC)Pancreatic neuroendocrine tumors
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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