rs957788

This is a intron variant variant in the NALF1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body weight

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.01
p 4.0e-9
N 928,679
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genetic variants associated with disordered eating
AssociationN=2,564Tracey D. Wade et al.(2013)· International Journal of Eating Disorders

This GWAS examined genetic variants associated with disordered eating in 2,564 female twins using four eating disorder phenotypes (anorexia nervosa spectrum, bulimia nervosa spectrum, purging via substances, and disordered eating behaviors). Six regions reached suggestive significance (p<5×10⁻⁷), implicating CLEC5A, LOC136242, TSHZ1, and SYTL5 for anorexia nervosa spectrum; NT5C1B for bulimia nervosa spectrum; and ATP8A2 for disordered eating behaviors. No variants reached genome-wide significance at p<10⁻⁸.

Traits studied:Anorexia nervosa spectrumBulimia nervosa spectrumDisordered eating behaviorsEating disordersPurging via substances
PubMedDOIMetascience Observatory

About NALF1

Predicted to contribute to stretch-activated, monoatomic cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all NALF1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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