rs9579646

This variant is located in the ALOX5AP gene.

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Research that mentions this SNP (2)

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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk
AssociationN=1,959Mahmoud Merhi et al.(2015)· Inflammation Research

Case-control study of 1,959 Lebanese subjects investigating genetic variants in inflammatory pathway genes and coronary artery disease (CAD) risk. Four variants showed significant associations: rs4769874 (ALOX5AP, OR=1.54, p=0.011), rs9579646 (ALOX5AP, OR=0.76, p=0.001), rs4646903 (CYP1A1, OR=1.68, p=0.019), and rs854560 (PON1, OR=1.36, p=0.017). A significant smoking-gene interaction was found with rs4646903 in current smokers (OR=0.52, p=0.037).

Traits studied:Coronary artery disease
PubMedDOIMetascience Observatory
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Association of ALOX5AP with ischemic stroke: a population-based case-control study
AssociationN=839Ritesh Kaushal et al.(2007)· Human Genetics

This population-based case-control study examined the association of ALOX5AP gene variants with ischemic stroke in 357 cases and 482 controls from the Greater Cincinnati/Northern Kentucky region. Among whites, rs4769874 showed significant association with ischemic stroke (P < 10^-4, OR = 4.95) and specific subtypes including cardioembolic (OR = 6.0) and large vessel stroke (OR = 3.9). Haplotype analysis identified the GTAAG haplotype significantly associated with stroke among whites (P < 10^-4), but no significant associations were found in the black population.

Traits studied:Cardioembolic strokeIschemic strokeLarge vessel strokeSmall vessel strokeStroke of unknown cause
PubMedDOIMetascience Observatory

About ALOX5AP

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

View all ALOX5AP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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