rs958685

This variant is located in the TGFA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

grip strength measurement

Willems SM et al. “Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.” Nature Communications 8:16015 (2017)
Allele A
OR 0.16
p 5.0e-13
N 142,035
Large GWAS
European
Jones G et al. “Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.” Nature Communications 12(1):654 (2021)
Allele A
OR 0.04
p 7.0e-9
N 256,523
Meta-analysisLarge GWAS
European

About TGFA

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

View all TGFA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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