rs9647379
This variant is located in the FNDC3B gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heart rate
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.02
p 3.0e-25
N 394,642
Large GWAS
European
den Hoed M et al. “Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.” Nature Genetics 45(6):621-31 (2013)
Allele C
OR 0.21
p 1.0e-9
N 92,355
Large GWAS
multi-ancestry
appendicular lean mass
Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele C
OR 0.02
p 3.0e-21
N 450,243
Major Consortium StudyLarge GWAS
European
Hernandez Cordero AI et al. “Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.” American Journal of Human Genetics 105(6):1222-1236 (2019)
Allele C
OR 0.04
p 2.0e-9
N 181,862
Large GWAS
European
BMI-adjusted waist-hip ratio
Lotta LA et al. “Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.” Jama 320(24):2553-2563 (2018)
Allele G
OR 0.01
p 3.0e-14
N 660,648
Large GWAS
European
hypertrophic cardiomyopathy
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele C
OR 1.20
p 8.0e-11
N 8,361
Large GWAS
European
Tadros R et al. “Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.” Nature Genetics 57(3):530-538 (2025)
Allele C
OR 0.18
p 4.0e-10
N 42,802
Large GWAS
European, African unspecified, Hispanic or Latin American, East Asian, South Asian, NR
waist-hip ratio
Lotta LA et al. “Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.” Jama 320(24):2553-2563 (2018)
Allele G
OR —
p 5.0e-8
N 663,598
Large GWAS
European
About FNDC3B
Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
View all FNDC3B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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