rs966423

This is a intron variant variant in the DIRC3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

thyroid carcinoma

Gudmundsson J et al. “Discovery of common variants associated with low TSH levels and thyroid cancer risk.” Nature Genetics 44(3):319-22 (2012)
Allele C
OR 1.34
p 1.0e-9
N 27,758
Large GWAS
European
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Research that mentions this SNP (1)

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Significant SNPs have limited prediction ability for thyroid cancer
AssociationN=1,850Shicheng Guo et al.(2014)· Cancer Medicine

Case-control study genotyping five thyroid cancer-associated SNPs (rs965513 OR=1.53, rs944289 OR=1.51, rs966423 OR=1.32, rs2439302 OR=1.40; rs116909374 not detected) in 845 Han Chinese papillary thyroid carcinoma cases and 1,005 controls. Although significant associations were confirmed, prediction accuracy was limited (AUC 0.54-0.60 across nine machine learning methods) with low sensitivity (0.28-0.48), indicating minimal clinical utility despite large odds ratios.

Traits studied:Papillary thyroid carcinomaThyroid cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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