rs9676509

This variant is located in the SULT2B1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cadherin-1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.04
p 6.0e-16
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival
AssociationN=1,765Shuwei Li et al.(2018)· Archives of Toxicology

A case-control study in Chinese population examining SNPs in estrogen metabolic pathway genes and colorectal cancer risk and survival. rs3760806 in SULT2B1 was significantly associated with colorectal cancer risk in both males (OR=1.38, 95% CI 1.15-1.66) and females (OR=1.38, 95% CI 1.13-1.68). Two SNPs in SULT1E1 (rs1238574 and rs3822172) were associated with poor progression-free and overall survival (HRs 1.24-1.53).

Traits studied:Colorectal cancer overall survivalColorectal cancer progression-free survivalColorectal cancer risk
PubMedDOIMetascience Observatory

About SULT2B1

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

View all SULT2B1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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