rs9692998

This variant is located in the EIF4EBP1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

ovulation

D'Urso S et al. “Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.” Bmc Medicine 20(1):419 (2022)

Allele T

OR 0.33

p 4.0e-14

N 118,227

Large GWAS

European

About EIF4EBP1

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

View all EIF4EBP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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