rs976212663

This variant is located in the AKR1B15 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

X-26054 measurement

Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)

Allele A

OR 2.08

p 4.0e-15

N 6,136

Large GWAS

European

About AKR1B15

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in estrogen biosynthetic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

View all AKR1B15 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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