rs9786153

This variant is located in the EIF1AY gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

autism

Alsubaie LM et al. “Risk Y-haplotypes and pathogenic variants of Arab-ancestry boys with autism by an exome-wide association study.” Molecular Biology Reports 47(10):7623-7632 (2020)
Allele T
OR 1.80
p 3.0e-9
N 90
Small GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
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Research that mentions this SNP (1)

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Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
AssociationN=7,810Wang Z. et al.(2012)· Human Genetics

Two-phase association study examining Y chromosome haplogroups and prostate cancer risk in 3,995 cases and 3,815 controls (Stage I) with replication in 1,272 European and 1,686 Ashkenazi Jewish cases. The rare E1b1b1c haplogroup showed nominally significant association with prostate cancer overall (P=0.012, OR=0.51; 95% CI 0.30-0.87) in Stage I, with meta-analysis of stages I and II revealing a nominally significant association with prostate cancer risk (P=0.010, OR=0.77; 95% CI 0.62-0.94).

Traits studied:aggressive prostate cancernon-aggressive prostate cancerprostate cancer
PubMedDOIMetascience Observatory

About EIF1AY

This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

View all EIF1AY variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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