rs9804200
This is a intron variant variant in the EBF3 gene.
▶Research that mentions this SNP (1)
▶A genome‐wide association study of sleep habits and insomniaAssociationN=4,357Enda M. Byrne et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Genome-wide association study of 2,323 Australian twins identified several associations with sleep phenotypes including sleep latency, sleep quality, sleep duration, and insomnia, but no genome-wide significant variants. Most notable finding: SNPs in CACNA1C intron 3 (rs7316184, rs7304986, rs7301906, and others) showed strongest association with sleep latency (p = 1.3 × 10⁻⁶), though this did not replicate in independent Chronogen Consortium sample. Additional associations with insomnia factor score (rs11174478 in SLC2A13, p = 1.92 × 10⁻⁶) and sleep duration (rs4780805, p = 2.66 × 10⁻⁶) were identified but remain unreplicated.
About EBF3
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
View all EBF3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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