rs9813813

This is a upstream gene variant variant in the KLHDC8B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hepatocyte growth factor-like protein level

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 1.04

p 2.0e-90

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

level of DNA repair protein XRCC1 in blood serum

Kuliesius J et al. “Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.” Communications Biology 8(1):1300 (2025)

Allele A

OR 0.96

p 9.0e-13

N 197

Small GWAS

European

About KLHDC8B

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

View all KLHDC8B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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