rs9834970

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

bipolar I disorder

Mullins N et al. “Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.” Nature Genetics 53(6):817-829 (2021)

Allele T

OR 0.90

p 1.0e-21

N 475,038

Large GWAS

European

Stahl EA et al. “Genome-wide association study identifies 30 loci associated with bipolar disorder.” Nature Genetics 51(5):793-803 (2019)

Allele T

OR 1.12

p 4.0e-14

N 46,237

Large GWAS

European

bipolar disorder

Mullins N et al. “Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.” Nature Genetics 53(6):817-829 (2021)

Allele T

OR 0.92

p 7.0e-19

N 413,466

Large GWAS

European

Ikeda M et al. “A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.” Molecular Psychiatry 23(3):639-647 (2018)

Allele T

OR 1.12

p 2.0e-9

N 81,582

Large GWAS

multi-ancestry

Li HJ et al. “Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals: A Genome-Wide Association Study and Meta-analysis.” Jama Psychiatry 78(3):320-330 (2021)

Allele T

OR 0.93

p 4.0e-12

N 58,182

Meta-analysisLarge GWAS

multi-ancestry

Stahl EA et al. “Genome-wide association study identifies 30 loci associated with bipolar disorder.” Nature Genetics 51(5):793-803 (2019)

Allele T

OR 1.08

p 6.0e-12

N 51,710

Large GWAS

European

Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)

Allele T

OR 0.09

p 3.0e-15

N 51,710

Large GWAS

European

Hou L et al. “Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.” Human Molecular Genetics 25(15):3383-3394 (2016)

Allele T

OR 1.14

p 5.0e-10

N 34,950

Large GWAS

European

Chen DT et al. “Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.” Molecular Psychiatry 18(2):195-205 (2013)

Allele T

OR —

p 1.0e-12

N 14,755

Meta-analysisLarge GWAS

multi-ancestry

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Research that mentions this SNP (2)

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Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta‐analysis

AssociationN=1,237Fayi Nie et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A case-control association study of 1,237 Pakistani subjects (479 with major depression, 222 with bipolar disorder, 146 with schizophrenia, 390 controls) examined 11 dopaminergic system gene variants. Significant risk associations were found for rs1006737 and rs2238056 (CACNA1c) with bipolar disorder (OR=1.14-1.15), while rs10033951 (DRD5), rs2388334 (POU3F2), and the DRD4 120bp VNTR showed protective effects across disorders (OR=0.81-0.86).

Traits studied:Bipolar DisorderMajor DepressionSchizophrenia

PubMed DOI Metascience Observatory

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Refinement of chromosome 3p22.3 region and identification of a susceptibility gene for bipolar affective disorder

AssociationN=411Rodrigo Secolin et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Family-based association study in 74 families (96 bipolar affective disorder patients) identified rs166508 in intron 15 of the ITGA9 gene as significantly associated with bipolar disorder (P=0.0187). The rs166508 A allele showed upregulation of ITGA9 transcripts (Kruskal-Wallis P=0.0339) and was associated with an intronic deletion (r.1689_1839del) affecting exon 16, which contains microRNA binding sites that may regulate ITGA9 expression.

Traits studied:Bipolar affective disorder (BPAD)

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs9834970

GWAS Catalog Trait Associations (2)

bipolar I disorder

bipolar disorder

Research that mentions this SNP (2)

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